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Moreover, often with vitamin B12 deficiency, a specific type of anemia called macrocytic anemia can be identified with a blood smear. Laboratory tests, specifically a complete blood count and a vitamin B12 level, can confirm a diagnosis of vitamin B12 deficiency.

Besides a medical history, which may reveal symptoms like unexplained fatigue or numbness and tingling, your physical examination may identify signs of vitamin B12 deficiency. Your medical team may consider a number of diagnoses in addition to vitamin B12 deficiency when working to explain your symptoms. Vitamin B12 is an important water-soluble vitamin, and deficiency is common. People with vitamin B12 deficiency are likely to experience a wide range of symptoms, though weight gain is unlikely one of them. Sources of vitamin B12 include animal foods, vitamin-B12-fortified foods, and supplements.

They’re especially handy for people with low levels of intrinsic factor, a protein that helps your body absorb vitamin B12 more easily . On the other hand, a vitamin B12 deficiency appears to cause a loss of appetite in some people, leading to weight loss rather than weight gain . Still, such observational studies cannot confirm whether low vitamin B12 levels are what caused the weight gain, nor whether they’re what protected against low levels.

They may take effect gradually—over weeks or months–and provide only a modest decrease in pain. When you combine supplements with other treatments, such as an anti-inflammatory diet and exercise, there may be weight loss more significant pain relief. Many supplement products aiming to treat arthritis contain both glucosamine and chondroitin sulfate. Research regarding glucosamine and chondroitin sulfate supplements is mixed,14-16 and doctors’ opinions of them vary.

• Always talk to your doctor before starting any new supplements or changing your treatment plan in any way.
• This may be because B vitamins can speed up nerve tissue regeneration and improve nerve function.
• A 2017 review indicates that supplementing with B vitamins has the potential to promote nerve repair.
• B vitamins may also be useful in relieving pain and inflammation.

Positive clinical studies suggest they may provide modest pain relief by helping to rebuild worn-out cartilage in your arthritic joints. However, I recommend an omega 3 supplement derived from plants, such as flax seeds. A plant-based supplement helps avoid the risk of mercury contamination found in some poorly manufactured fish oil supplements. A plant-based omega-3 supplement may also be preferable if you follow a vegetarian or vegan diet. Keep in mind that omega 3 fatty acids in fish oil can be different than those in plant-based sources.

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Vitamin B-12 injections or nasal spray might be prescribed to treat vitamin B-12 deficiency. Also, keep in mind that supplements are not a quick fix for your arthritis pain.

(Fish oil contains eicosapentaenoic acid and docosahexaenoic acid while flax seeds, for example, contain alpha-linolenic acid .) This difference may affect the dosage. Several studies have found that vitamin B12 plays a role in controlling bone metabolism. Another study found that people with osteoarthritis have low intake of vitamin B9 . Depending on the reason for your vitamin deficiency, you may need to continue to use lifelong supplementation with vitamin B12 even after your symptoms improve.